[HTML][HTML] Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes
V Bezaire, A Mairal, C Ribet, C Lefort… - Journal of Biological …, 2009 - ASBMB
Lipolysis is the catabolic pathway by which triglycerides are hydrolyzed into fatty acids.
Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) have the capacity to
hydrolyze in vitro the first ester bond of triglycerides, but their respective contributions to
whole cell lipolysis in human adipocytes is unclear. Here, we have investigated the roles of
HSL, ATGL, and its coactivator CGI-58 in basal and forskolin-stimulated lipolysis in a human
white adipocyte model, the hMADS cells. The hMADS adipocytes express the various …
Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) have the capacity to
hydrolyze in vitro the first ester bond of triglycerides, but their respective contributions to
whole cell lipolysis in human adipocytes is unclear. Here, we have investigated the roles of
HSL, ATGL, and its coactivator CGI-58 in basal and forskolin-stimulated lipolysis in a human
white adipocyte model, the hMADS cells. The hMADS adipocytes express the various …