In normal human placentation, uterine invasion by trophoblast cells and subsequent spiral
artery remodeling depend on cooperation among fetal trophoblasts and maternal decidual,
myometrial, immune and vascular cells in the uterine wall. Therefore, aberrant function of
anyone or several of these cell-types could theoretically impair placentation leading to the
development of preeclampsia. Because trophoblast invasion and spiral artery remodeling
occur during the first half of pregnancy, the molecular pathology of fetal placental and …