[HTML][HTML] Tryptophan catabolism is dysregulated in leiomyomas
Objective To determine the expression and functional roles of indoleamine 2, 3-dioxygenase
1 (IDO1) and tryptophan 2, 3-dioxygenase (TDO2) in leiomyoma. Design Experimental
study. Setting Academic research laboratory. Patient (s) Women undergoing hysterectomy
for leiomyoma. Intervention (s) Blockade of IDO1 and TDO2. Main Outcome Measure (s)
Expression of IDO1 and TDO2 in leiomyoma and the effects of their inhibitors on the
extracellular matrix. Result (s) Leiomyoma expressed significantly higher levels of IDO1 and …
1 (IDO1) and tryptophan 2, 3-dioxygenase (TDO2) in leiomyoma. Design Experimental
study. Setting Academic research laboratory. Patient (s) Women undergoing hysterectomy
for leiomyoma. Intervention (s) Blockade of IDO1 and TDO2. Main Outcome Measure (s)
Expression of IDO1 and TDO2 in leiomyoma and the effects of their inhibitors on the
extracellular matrix. Result (s) Leiomyoma expressed significantly higher levels of IDO1 and …