Aryl hydrocarbon receptor (AHR):“pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals
DW Nebert - Progress in lipid research, 2017 - Elsevier
The basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family comprises many transcription
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense”
innumerable intracellular and extracellular “signals”—including endogenous compounds,
foreign chemicals, gas molecules, redox potential, photons (light), gravity, heat, and osmotic
pressure. These signals then initiate downstream signaling pathways involved in
responding to that signal. The term “PAS”, abbreviation for “per-Arnt-sim” was first coined in …
factors, found throughout all three kingdoms of life; bHLH/PAS members “sense”
innumerable intracellular and extracellular “signals”—including endogenous compounds,
foreign chemicals, gas molecules, redox potential, photons (light), gravity, heat, and osmotic
pressure. These signals then initiate downstream signaling pathways involved in
responding to that signal. The term “PAS”, abbreviation for “per-Arnt-sim” was first coined in …