Forkhead box P3–expressing regulatory T (Treg) cells are essential for self-tolerance, with
an emerging role in tissue repair and regeneration. Their ability to traffic to tissue and
perform complex therapeutic tasks in response to the tissue microenvironment make them
an attractive candidate for drug development. Early experiences of Treg cell therapy in
patients with graft-versus-host disease, type 1 diabetes, and organ transplantation have
shown that it is feasible, safe, and potentially efficacious in some settings. Many ongoing …