Sphingosine 1-phosphate activates nuclear factor-κB through Edg receptors: activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells
S Siehler, Y Wang, X Fan, RT Windh… - Journal of Biological …, 2001 - ASBMB
Sphingosine 1-phosphate (S1P) exerts a variety of actions as a second messenger or as an
agonist that binds to one or more members of the Edg family of G protein-coupled receptors.
By using human embryonic kidney 293 cells, we show that S1P activates nuclear factor-κB
(NF-κB) in a receptor-dependent fashion. Edg-3 and Edg-5, which are coupled to G i, G q,
and G 13, affect activation of NF-κB, whereas Edg-1, which is coupled to G i alone, does not.
We find that the activation of NF-κB requires protein kinase C and Ca 2+, probably …
agonist that binds to one or more members of the Edg family of G protein-coupled receptors.
By using human embryonic kidney 293 cells, we show that S1P activates nuclear factor-κB
(NF-κB) in a receptor-dependent fashion. Edg-3 and Edg-5, which are coupled to G i, G q,
and G 13, affect activation of NF-κB, whereas Edg-1, which is coupled to G i alone, does not.
We find that the activation of NF-κB requires protein kinase C and Ca 2+, probably …