A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies
MA Nalls, R Duran, G Lopez, M Kurzawa-Akanbi… - JAMA …, 2013 - jamanetwork.com
Importance While mutations in glucocerebrosidase (GBA1) are associated with an increased
risk for Parkinson disease (PD), it is important to establish whether such mutations are also a
common risk factor for other Lewy body disorders. Objective To establish whether GBA1
mutations are a risk factor for dementia with Lewy bodies (DLB). Design We compared
genotype data on patients and controls from 11 centers. Data concerning demographics,
age at onset, disease duration, and clinical and pathological features were collected when …
risk for Parkinson disease (PD), it is important to establish whether such mutations are also a
common risk factor for other Lewy body disorders. Objective To establish whether GBA1
mutations are a risk factor for dementia with Lewy bodies (DLB). Design We compared
genotype data on patients and controls from 11 centers. Data concerning demographics,
age at onset, disease duration, and clinical and pathological features were collected when …
