IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin
N Malhotra, J Yoon, JM Leyva-Castillo… - Journal of Allergy and …, 2016 - Elsevier
Background Staphylococcus aureus is an opportunistic pathogen that colonizes the skin of
patients with atopic dermatitis (AD) and aggravates their disease. Neutrophils and the
cytokines IL-17A and IL-17F, which drive the expression of the neutrophil-attracting
chemokines, are important for the clearance of S aureus infection. The cytokine IL-22 is often
coproduced by IL-17–secreting cells. The levels of IL-22 are elevated in AD skin lesions.
Objective We sought to determine the role of IL-22 in the clearance of S aureus infection of …
patients with atopic dermatitis (AD) and aggravates their disease. Neutrophils and the
cytokines IL-17A and IL-17F, which drive the expression of the neutrophil-attracting
chemokines, are important for the clearance of S aureus infection. The cytokine IL-22 is often
coproduced by IL-17–secreting cells. The levels of IL-22 are elevated in AD skin lesions.
Objective We sought to determine the role of IL-22 in the clearance of S aureus infection of …