Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect
RA Eliseev, J Malecki, T Lester, Y Zhang… - Journal of biological …, 2009 - ASBMB
Cyclophilin D (CypD) is a mitochondrial immunophilin and a key positive regulator of the
mitochondrial permeability transition (MPT). Several reports have shown that CypD is
overexpressed in various tumors, where it has an anti-apoptotic effect. Because the MPT is a
cell death-inducing phenomenon, we hypothesized that the anti-apoptotic effect of CypD is
independent of the MPT but is due to its interaction with some key apoptosis regulator, such
as Bcl2. Our data indicate that CypD indeed interacts with Bcl2 as confirmed with co …
mitochondrial permeability transition (MPT). Several reports have shown that CypD is
overexpressed in various tumors, where it has an anti-apoptotic effect. Because the MPT is a
cell death-inducing phenomenon, we hypothesized that the anti-apoptotic effect of CypD is
independent of the MPT but is due to its interaction with some key apoptosis regulator, such
as Bcl2. Our data indicate that CypD indeed interacts with Bcl2 as confirmed with co …
